簡介：A group of five young friends travel from Los Angeles to exotic Panama for a week of partying in lush tropical paradise. Befriending a beautiful local woman in their hotel bar, they learn of a secret jungle hike to a pristine waterfall nearby. The woman cautions them strongly against the hike, warning that other gringos in search of the legendary waterfall had mysteriously disappeared into the jungle, never to be seen or heard from again. Ignoring her warnings, the group convinces the woman to guide them to the picturesque waterfall, thinking that they have nothing to fear with a local as their guide. What begins as a fun outing quickly turns terrifying when their guide mysteriously vanishes after a romantic tryst at the falls. As night closes in, the friends realize too late the truth behind her warnings— horrific, bloodthirsty, flesh-eating creatures are now stalking them. The mangled survivors rush to jungle caves for shelter, only to realize they’ve entered the monsters’ lair!
After two women are attacked on a desolate road they take refuge at the home of a kind-hearted stranger named Saul who harbors the dark secret of lycanthropy. Can a professor experimenting with the secrets of the Pharaohs cure Saul, or will a battle between the Werewolf and a freshly reanimated Mummy be the end for them all?
埃文（本·斯蒂勒 Ben Stiller 飾）是鎮(zhèn)上的一個商店經(jīng)理，對區(qū)的事務也十分積。然而商店保安卻遇了意外謀殺，當警察卻無心追查，文的生活就此被打，他決心自己找出手。埃文將目光投了鄰里街坊，并與樣在生活中受挫的勃（文斯·沃恩 Vince Vaughn 飾）、富蘭克林（喬納·希爾 Jonah Hill 飾）和賈馬克思（理查德·艾歐阿德 Richard Ayoade 飾）四人組成了鄰里聯(lián)防，每天在鎮(zhèn)上巡邏當然也借此理由偶放縱。在一次駕車邏時，他們意外地現(xiàn)了一個奇怪的金球，與此同時，鎮(zhèn)也出現(xiàn)了幾起神秘亡事件，聯(lián)防組在一只外來生物攻擊制服了它，得知外人已經(jīng)入侵小鎮(zhèn)，且通過偷竊人類皮來偽裝成人，施展勢。聯(lián)防組方知行已經(jīng)迫在眉睫但卻里看花，因為小鎮(zhèn)的任何一個人都可是外星人，然而更怕的是，外星人的終目的竟然是毀滅個地球。得知這一的聯(lián)防組能否憑四之力粉碎外星人的謀呢…?
