Pharmacists check prescription information at a fever clinic in Minhang district of Shanghai on Jan 8. The small molecule drugs to treat COVID-19 had been put into use in community health centers in Shanghai to better play their roles in "early detection, early intervention and early diversion". WANG XIANG/XINHUADomestically?developed?COVID-19?drug?therapies?lower?risk?of?hospitalizationChina will create broad-spectrum treatments to tackle mutated strains of the COVID-19 virus and develop drugs with novel mechanisms to fight the pathogen, according to a document provided to China Daily.As of Jan 19, a total of 10 domestically made COVID-19 drugs had either been granted official or conditional market approval or were authorized to treat symptoms of the pathogen, the document stated.The document was issued by the specialized team for COVID-19 medicine research and development under the Joint Prevention and Control Mechanism of the State Council, China's Cabinet.China also had 23 drugs on the key COVID-19 medicine list that were in active development or undergoing real-world evidence studies after receiving market approval, it said."The team will continue to facilitate the development of safe and effective treatments that can cover the whole course of the disease and are suitable for all populations," it added.Since the COVID-19 pandemic began, China's novel coronavirus drug development process has followed three broad technical paths- stopping the virus from entering cells, inhibiting viral replication in the body and regulating the body's immune system.In December 2021, China granted official market approval to its first homegrown neutralizing monoclonal neutralizing antibody cocktails - BRII-196 and BRII-198. It is a combination therapy administered through intravenous infusion that can lower the risk of hospitalization and death by nearly 80 percent, according to its phase-three clinical trial results.Meanwhile, Chinese scientists have been developing small-molecule oral treatments for COVID-19.A breakthrough came in July when China granted conditional authorization for the oral antiviral Azvudine to treat COVID-19. The drug was originally used to treat HIV.This year, China will accelerate the development of small-molecule oral drugs. In mid-January, the National Medical Products Administration received applications for market approval for new antivirals SIM0417 and VV116. Another antiviral called RAY1216 had recently finished recruiting for its late-stage clinical trials.Besides finding treatments for COVID-19, Chinese scientists are researching new drugs to prevent infections or regulate the body's immune system, with a handful of candidates currently in phase two or three clinical trials. Some notable examples include the targeted inhibitor drug TDI01 and HY3000 peptide nasal spray.zhangzhihao@chinadaily.com.cn 編輯：王犀牛
Tourists visit Great Tang All Day Mall in Xi'an, capital of Northwest China's Shaanxi province, Dec 30, 2022. [Photo/Xinhua]The past three years have been a steep learning curve in handling COVID-19 patients for Dang Shuangsuo, an epidemiologist in Xi'an, Shaanxi province.At the outset of the pandemic, when the deadlier variants of the virus were sweeping the globe, just a few antivirus drugs and herbal medicine prescriptions commonly used for seasonal flu were available for Dang to treat COVID patients.He and his colleagues were then not so sure about what parameters to monitor in patients so that they could intervene before mild symptoms morphed into life-threatening conditions.In the beginning, he recalled, no diagnosis and treatment plans had yet been tailor-made for specific age groups, such as elderly patients and young children.Adhering to the country's consistent principle of always putting people's lives and health first, Dang and his peers have witnessed the systemic evolution over the past three years of measures in terms of virus containment, treatment knowledge, response procedures, drugs and vaccines, thanks to tremendous resources mobilized by the authorities at all levels.By the time China optimized its COVID-19 control measures at the end of last year in light of the decreasing virulence of Omicron subvariants, Dang, the director of the infectious diseases department of the Second Affiliated Hospital of Xi'an Jiaotong University in Shaanxi province, said that the Chinese medical community was much better equipped and experienced to tackle novel coronavirus infections compared with three years ago.COVID medicines such as the domestically developed Azvudine, the Pfizer-made Paxlovid, and Molnupiravir manufactured by Merck& Co have been approved for clinical use in China, while more efficient and convenient vaccines, including an inhalable one, were made available last year for people seeking an extra layer of protection.Rules have been clarified over when antibiotics can be used on COVID patients, promoting the proper use of drugs and reducing antibiotic resistance.Meanwhile, efforts to add more critical care beds and to raise the inoculation rate among older adults were also picking up.In addition, a newly released diagnosis and treatment plan for severely ill COVID patients listed blood oxygen saturation under 93, among other body indexes, as a warning sign of a deteriorating condition, making it easier for doctors to take action before it's too late."Over the past three years, COVID-19 changed from an unknown virus into a better-known one," said Dang, who is also vice-chairman of Shaanxi's expert panel for the prevention and treatment of major infectious diseases.Dang was well aware that being cautious in terms of COVID-19 control policy is an inevitable choice for the Chinese government, given the country's vast population, fast-aging demographics and the uneven distribution of medical resources.Due to the country's large population, China's hospitals are susceptible to being overstretched if outbreaks spread unchecked.In addition, National Bureau of Statistics figures showed that China had 280 million people aged 60 and over by the end of last year, and this is the age group that the National Health Commission said this month accounts for almost 90 percent of severely ill COVID cases.For much of the past three years, China was under tremendous pressure to abandon its stringent COVID-19 control measures.As the virus' lethal variants interrupted life worldwide, some Western - countries, where factories were forced to shut down as workers fell sick - attempted to shift the blame to China, where lives largely returned to normal due to strict controls over infections - for disrupting global supply chains.However, China stood its ground and kept its border controls in place until January. By this time, the dominant Omicron subvariants were much less deadly than their predecessors, and more than 90 percent of the Chinese people were vaccinated.On Jan 8, China downgraded the management of the virus, so that inbound travelers no longer have to undergo quarantine or take a nucleic acid test upon arrival.The three years of strict control of international travel, together with efforts to nip every domestic outbreak in the bud, have bought precious time for experts such as Dang to learn more about COVID-19 as they approve new treatments, develop more effective vaccines and make new diagnosis and treatment plans for COVID-19 patients.Fine-tuning?measures"China has taken very small steps, but it has never stopped fine-tuning its COVID control measures as the virus mutates," he said, echoing comments made in November by Vice-Premier Sun Chunlan.The authorities in China have maintained that the nation was taking "small but nonstop steps" in fine-tuning its COVID response strategy, while staunchly adhering to the ultimate mission to safeguard people's health and lives.The gradual nature of the change was manifested in the 10 editions of pandemic control plans released over the course of three years, as well as the landmark documents colloquially known as the "20 measures" and the "10 new measures", unveiled in November and December, respectively.Since February 2020, the first six of the contagion control plans were published in slightly more than a month, when understanding of the virus was still unclear and little clinical data was available.On Jan 7, China released the 10th and latest edition, highlighting vaccination and personal protection.Just two days ahead of the eve of Spring Festival this month, health officials appeared at a news conference on Jan 19 with an encouraging message.Guo Yanhong, director of the National Health Commission's medical emergency department, said the number of COVID-19 patients had declined significantly at health facilities nationwide, from fever clinics and emergency centers to critical care wards. Meanwhile, the overwhelming majority of outpatients and hospitalizations were seeking treatment for conditions other than COVID-19.Data provided by the Chinese Center for Disease Control and Prevention showed that the positive test rate dropped from 29.2 percent to 5.5 percent between Dec 25 and Monday. The number of deaths from COVID-19 infections in hospitals nationwide dropped 79 percent from the peak on Jan 4 to 896 on Monday.To bolster the treatment capacity in rural regions, Dang had championed a simplified treatment plan for grassroots doctors, so that they can quickly identify COVID patients and ensure their condition does not worsen.His efforts, coupled with the central authorities' moves to bolster investment in the healthcare system in the countryside and beyond, managed to tide the rural population over a surge of infections last month, and helped contribute to China's success in keeping its COVID death rate among the lowest in the world.According to the National Health Commission in July, despite the intense challenges resulting from the pandemic, China's average life expectancy continued to rise amid the pandemic, from 77.93 years in 2020 to 78.2 years in 2021.Meanwhile, according to the National Center for Health Statistics, which is part of the United States' Centers for Disease Control and Prevention, average life expectancy in the US fell over the same period from 77 years in 2020 to 76.1 years in 2021. The total number of COVID-related deaths in the US reached 1.1 million by January, according to the CDC.Pointing to China's record in handling the pandemic over the past three years, Dang pointed out that,"Protecting vulnerable groups is a mission for a socialist society." 編輯：王?
